On November 1st, 2022, the Centers for Medicare and Medicaid Services (CMS) released its Medicare Physician Fee Schedule (PFS) Final Rule which makes changes to the Quality Payment Program (QPP) for 2023 and future performance years. The rule provides policy updates to the traditional Merit-based Incentive Payment System (MIPS) program, the new MIPS Values Pathway (MVPs) framework, Alternative Payment Models (APMs), and Accountable Care Organizations (ACOs). This article provides a summary of the key provisions in the Final Rule.