Navigating the complexities of the Merit-based Incentive Payment System (MIPS) can be challenging, but understanding the Quality category is crucial for clinicians aiming to optimize their performance scores. As we approach the midpoint of the 2024 MIPS reporting year, clinicians should already be actively collecting and reporting data on their Quality measures. The Centers for Medicare and Medicaid Services (CMS) has announced that it is not accepting hardship applications due to COVID-19 for the 2024 performance year, so some clinicians may find themselves reporting MIPS for the first time in several years and discover that a lot has changed. This article will provide an in-depth overview of the 2024 Quality reporting requirements, changes to quality measures, and tips for selecting the best measures for one's practice.