We have almost reached the halfway mark for the 2022 MIPS performance year, so clinicians should be actively collecting and reporting data on their Quality measures. Each year the Centers for Medicare and Medicaid Services (CMS) updates the list of Quality measures eligible clinicians and groups can report under the MIPS program. Some measures get added to or deleted from the inventory, while other measures go through substantial revisions. This article summarizes important changes to the 2022 Quality Measures so that clinicians can make sure their data collection and reporting is on the right track.